Abstract
The reaction of alkyl phenyl sulfones ( 1) with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in the presence of a carbonyl compound or chlorotrimethylsilane (Barbier-type conditions) in THF at temperatures ranging between −78 and 20°C leads, after hydrolysis, to the expected products ( 2) arising from the corresponding alkyllithium generated in situ. When the same methodology is applied to sulfolene ( 3) or different alkyl phenyl sulfoxides ( 6), cyclic sulfinates 5 or products 2 are, respectively, obtained, the yields being, in general modest.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
