Nanosuspension: A Potential Nanoformulation for Improved Delivery of Poorly Bioavailable Drug

Abstract

Nanotechnology is the study, design, creation, synthesis, manipulation, and application of functional materials, devices, and delivery systems through control of matter at the nanometer scale. These include nanovectors, nanotubes, nanosensors, nanowires and nanocantilever arrays, nanopores and nanoformulations. These advances will lead to significant applications relevant to the diagnosis, management, and in the treatment of many diseases. The application of nanotechnology has attracted much interest as a new approach to deliver poorly soluble drugs in the form of colloidal nano-dispersion “nanosuspension” due to flexibility in processing during manufacturing and benefits like, improvement in oral bioavailability, high drug loading, and targeting capabilities and so on. Nanosuspensions formulation was found to be an efficient delivery system for oral as well as non oral routes like parenteral, ocular, pulmonary and targeted delivery. In this article, we will highlight formulation aspects of nanosuspensions in the light of a brief introduction to the pharmaceutical technology and will summarize the application of nanosuspensions via a variety of administration routes. Keywords: Nanotechnology, nanosuspension, oral delivery, pulmonary delivery, parenteral delivery, drug targeting, bioavailability.