Abstract
Plant extracts are highly valuable pharmaceutical complexes recognized for their biological properties, including antibacterial, antifungal, antiviral, antioxidant, anticancer, and anti-inflammatory properties. However, their use is limited by their low water solubility and physicochemical stability. In order to overcome these limitations, we aimed to develop nanostructured carriers as delivery systems for plant extracts; in particular, we selected the extract of Anthriscus sylvestris (AN) on the basis of its antimicrobial effect and antitumor activity. In this study, AN-extract-functionalized magnetite (Fe3O4@AN) nanoparticles (NPs) were prepared by the co-precipitation method. The purpose of this study was to synthesize and investigate the physicochemical and biological features of composite coatings based on Fe3O4@AN NPs obtained by matrix-assisted pulsed laser evaporation technique. In this respect, laser fluence and drop-casting studies on coatings were performed. The physical and chemical properties of laser-synthesized coatings were investigated by scanning electron microscopy, while Fourier transform infrared spectroscopy comparative analysis was used for determining the chemical structure and functional integrity. Relevant data regarding the presence of magnetic nanoparticles as the only crystalline phase and the size of nanoparticles were obtained by transmission electron microscopy. The in vitro toxicity assessment of the Fe3O4@AN showed significant cytotoxic activity against human adenocarcinoma HT-29 cells after prolonged exposure. Antimicrobial results demonstrated that Fe3O4@AN coatings inhibit microbial colonization and biofilm formation in clinically relevant bacteria species and yeasts. Such coatings are useful, natural, and multifunctional solutions for the development of tailored medical devices and surfaces.
Highlights
Cancer is one of main causes of death worldwide, and the number of cancer-affected patients is ever-increasing [1,2]
The antiproliferative effects of the roots and aerial part of Anthriscus sylvestris (AN) showed a high in vitro inhibitory activity against MK-1, HeLa, and B16F10 tumor cell growth [43]. These results show that AN extract may have a multifunctional effect as a potent antimicrobial and anticarcinogenic agent
Our findings by means of High-Performance Liquid Chromatography (HPLC)-DD method revealed the presence of nine polyphenols
Summary
Cancer is one of main causes of death worldwide, and the number of cancer-affected patients is ever-increasing [1,2]. Colorectal cancer is the third most common type of cancer in the US and the second leading cause of cancer deaths; it was estimated that new cases of colorectal cancer will reach ~133,000/year in the five years [3,4]. Colorectal cancer has been in the center of epidemiological research, with the main scope being the determination of causative factors for this disease. Several scientific studies have focused on the part played by microbes in colorectal cancer etiology [7,8]. Evidence has shown that colonic adenomas, carcinomas, and the mucosa of colorectal cancer are inhabited by high numbers of adhering
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