Abstract
Many functional substances are hardly dissolved in water or lipid at ambient temperature, which causes some difficulties in product formulation. Therefore, the aim of this research was to develop a novel carrier system by complexing nanostructured lipid carriers (NLC) with mesoporous silica nanoparticles (MSN), which can be used to dissolve lipid-insoluble functional substances or control the release of volatile compounds. A lipid-insoluble antioxidant (quercetin) and a labile volatile compound (limonene) were used as model compounds incorporated into this system. The performance of antioxidant activity of quercetin (QT) on the lipid photo-oxidation of NLC, and the release rate and stability of limonene during the manufacturing process and photo-oxidation were investigated. The addition of MSN-QT greatly improved the lipid stability of NLC during photo-oxidation. Both sheltering effect and antioxidant activity of MSN enhanced the performance of the added antioxidant against the photo-oxidation of NLC. The release rate of limonene was markedly reduced, and photo-stability of limonene was enhanced in this NLC-MSN system.
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