Abstract
Nanosized titanium dioxide material. Modulation of spontaneous motility and gaba-dependent regulation of functions of stomach smooth muscles in vivo
Highlights
Current development of high technologies, became the foundation for extensive production of nanosized materials, in particular, titanium dioxide (ТіО2), whose applica tion takes a large sector of different kinds of industry, including pharmacological indus try, the sphere of food production and medicine
The intake of TiO2 to human organism takes place with food, water, and air, and the main ways of its transportation are gastrointestinal tract (average daily amount of consumed ТіО2 (0.002–5) mg and respiratory tracts [14, 16, 22], which in the global practice may already be referred to the nanohazard problems in the sphere of Environmental and Health Safety
It was stated that the intake route of nanosized TiO2 material to human organism via the gastrointestinal tract is the most probable, and food impact in the gastric cavity is the longest compared to other gastrointestinal tract parts
Summary
Current development of high technologies, became the foundation for extensive production of nanosized materials, in particular, titanium dioxide (ТіО2), whose applica tion takes a large sector of different kinds of industry, including pharmacological indus try, the sphere of food production and medicine. The mechanisms of releasing these cations from rianodine- and IP3-sensitive stores of sarcoplasmic reticulum were not sensitive to the impact of TiO2 It was demon strated [21] that in vitro ТіО2 in smooth muscles of large intestines modulated histamine and nicotine-induced mechanisms of regulating its functional activity. The aim of this work was to study changes in vivo in spontaneous motility and GABA-dependent regulation of functions of stomach smooth muscles, caused by chronic effect of nanosized TiO2 material
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
