Nanosized catalysts in fine organic synthesis as a basis for developing innovative technologies in the pharmaceutical industry

Abstract

This investigation of the catalytic properties of noble metal nanoparticles stabilized in hypercrosslinked polystyrene (HPS) matrix shows the prospect for their application in regioselective oxidation region- and enantioselective hydrogenation, which represent key stages for the synthesis of the intermediates and final products of pharmaceutical industry. Commercial use of nanosized catalysts allows shortening the synthetic stages, increasing product yields, and improving the environmental safety of the existing industrial processes. In this review, the synthesis, structure and catalytic properties of mono- (Pt, Ru, Pd), bi- (Pt-Pd, Pt-Ru, Pd-Ru), and trimetallic (Pt-Pd-Ru) nanoparticles stabilized in the pores of a polymeric HPS matrix are discussed. Physicochemical investigations have shown that the formation of metal-containing nanoparticles depends on the properties of the porous polymeric structure, the nature of the initial metal precursor, and the synthesis conditions. The use of nanosized catalysts is revealed to be effective in the most important field of fine organic synthesis: preparation of materials for medicine, vitamins, and food additives (e.g., in the food and pharmaceutical industry).