Abstract
Superresolution imaging techniques have provided a better understanding of the relationship between nanoscale organization and function of the ryanodine receptors (RyRs) and, consequently, the impact of organization on calcium spark properties in heart failure (HF). While hyperphosphorylation of RyRs is generally observed during HF, the impact of RyR phosphorylation on calcium (Ca2+) sparks remains incompletely understood because several experimental studies show seemingly contradictory results.
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