Nanoprobe Design: Integrated Fluorescent Nanoprobe Design for High‐Speed In Vivo Two‐Photon Microscopic Imaging of Deep‐Brain Vasculature in Mice (Adv. Funct. Mater. 20/2021)

Abstract

In article number 2010698, Yosuke Niko and co-workers report a novel dye-loaded nanoemulsion for high-speed two-photon microscopic imaging of the deep-brain vasculature in mice. The nanoprobe fully exploits the performance of a Ti:sapphire laser and a gallium arsenide phosphide detector, allowing the visualization of hippocampal blood flow in mice at a high frame rate of 120 fps.