Nanoparticles associated with antimicrobial peptides (AMPs)  promising combination for biomedical and veterinary applications

Abstract

Bacterial resistance to classical antibiotics is a growing concern, and scientists are seeking alternative methods to combat bacterial infections. One promising option is the use of antimicrobial peptides (AMPs) with strong antibacterial activity provided with diverse mechanisms, including membrane disruption, intracellular interference, and inhibition of bacterial metabolic processes. They can also modulate inflammation, enhancing antimicrobial effects. Compared to antibiotics, AMPs can have a broader range of activity and are less prone to bacterial resistance. However, their use has limitations, such as a short half-life and proteolytic degradation. To address these challenges, researchers are developing strategies to enhance the stability and efficacy of AMPs, including the use of nanocarriers. Nanocarriers, such as inorganic particles, liposomes, polymeric particles, cubosomes, and quantum dots can improve the stability of AMPs, protect them from degradation, enhance their penetration into bacterial cells, and increase their antibacterial activity. Nanocarriers can also boost AMPs absorption by bacteria and stimulate their enzymatic function. While nanocarriers show promise in enhancing AMPs efficacy and stability, further research is necessary to determine their safety and effectiveness in practical medical applications. This review offers a succinct exploration of specific nanoparticles, their function as carriers for AMPs, and their potential significance in both medical and veterinary contexts.