Nano-micro materials regulated biocatalytic metabolism for efficient environmental remediation: Fine engineering the mass and electron transfer in multicellular environments

Abstract

The escalating energy and environmental crises have spurred significant research interest into developing efficient biological remediation technologies for sustainable contaminant and resource conversion. Integrating engineered nano-micro materials (NMMs) with these biocatalytic processes offers a promising approach to improve the microbial performance for environmental remediation. Core to such material-enhanced hybrid biocatalysis systems (MHBSs) is the rational regulation of metabolic processes with the assistance of NMMs, where a fine engineered mass and electron transfer is beneficial for the improved biocatalytic activity. However, the specific mechanisms of those NMMs-enhanced microbial metabolisms are normally overlooked. Here, we review the recent progress in MHBSs, focusing primarily on the mass/electron transfer regulation strategies for an enhanced microbial behavior. Specifically, the NMMs-regulated mass and electron transfer in extracellular, interfacial, and intracellular environment are summarized, where the patterns of diverse microbiological response are discussed thoroughly. Notably, fine modifications of cell interfaces and intracellular compartments by NMMs could even endow the biohybrids with new metabolic functions beyond their natural capabilities. Further, we also emphasize the importance of matching the various metabolic demands of biosystems with the diverse properties of NMMs to achieve efficient environmental remediation through a coordinated regulation strategy. Finally, major challenges and opportunities for the future development and practical implementation of MHBSs for environment remediation practices are given, aiming to provide future system design guidelines for attaining desirable biological behaviors.