Nanometals: As click catalysts for 1,4-triazole cycloaddition (2020-till date)

Abstract

In recent years, the search for efficient and sustainable catalysts for click chemistry has gained significant attention. The process of copper-catalyzed azide-alkyne cycloaddition (CuAAC) has many applications in medicinal chemistry and chemical biology. This review focuses on the numerous properties, synthetic approaches, and most recent advancements in the "click" catalyst-based nanometal catalyzed azide-alkyne cycloaddition (nMAAC), which utilizes a variety of metals (Ir, Zn, La, Ag, Au, Ru). The introduction of click chemistry has left a significant impact on virtually all subfields that are included in the field of chemical research. This comprehensive analysis of the synthetic technique, includes the development of new catalyst methods to produce the triazoles. By incorporating the synthetic approach with the technique that emphasizes preferred substructures via biorthogonal reactions, using cutting-edge mechanization and flow technologies, the productivity can be increased. The article discusses the synthesis and characterization of different nanometals employed as click catalysts, along with the optimization of reaction conditions to obtain high yields of 1,4-triazole products. The paper concludes by highlighting the potential applications of these Nano catalysts in developing new materials for various fields, including bioconjugation, materials science, and pharmaceuticals.