Abstract
Elasticity is a key property of DNA. Throughout the cell cycle, DNA is subjected to mechanical loadings that deform its original structure. Beyond the biological significance of DNA elasticity, in DNA nanotechnology, a solid understanding of DNA reaction to force is necessary to create functional nanostructures. We characterize the elastic profile of different canonical DNA double helical structures, specifically the A and Z helices, by stretching with atomic force microscope (AFM) based single-molecule force spectroscopy.
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