Nanomaterials for Biosensors

Abstract

Preface. List of Authors. 1 Biosensing using Carbon Nanotube Field-effect Transistors (Padmakar D. Kichambare and Alexander Star). 1.1 Overview. 1.2 Introduction. 1.3 Carbon Nanotube Field-effect Transistors (NTFETs). 1.4 Sensor Applications of NTFETs. 1.5 Conclusion and Outlook. 2 Carbon Nanotube-based Sensor (Jian-Shan Ye and Fwu-Shan Sheu). 2.1 Overview. 2.2 Introduction of Carbon Nanotubes. 2.3 Growth of Carbon Nanotubes. 2.4 Methods to Prepare CNTs-based Sensors and Biosensors. 2.5 Application of CNTs-based Electrochemical Sensors and Biosensors. 2.6 Functionalization of CNTs. 2.7 Conclusions and Future Prospects. 3 Nanotubes, Nanowires, and Nanocantilevers in Biosensor Development (Jun Wang, Guodong Liu, and Yuehe Lin). 3.1 Introduction. 3.2 Carbon Nanotubes in Biosensor Development. 3.3 Nanowires in Biosensor Development. 3.4 Nanocantilevers for Biosensors. 3.5 Summary. 4 Fullerene-based Electrochemical Detection Methods for Biosensing (Nikos Chaniotakis). 4.1 Introduction. 4.2 Aims of the Chapter. 4.3 Electrochemical Biosensing. 4.4 Evolution of Biosensors. 4.5 Mediation Process in Biosensors. 4.6 Fullerenes. 4.7 Fullerene-mediated Biosensing. 4.8 Conclusions. 5 Optical Biosensing Based on Metal and Semiconductor Colloidal Nanocrystals (Roberto Comparelli, Maria Lucia Curri, Pantaleo Davide Cozzoli, and Marinella Striccoli). 5.1 Overview. 5.2 Introduction. 5.3 Colloidal Nanocrystals. 5.4 Nanocrystal Functionalization for Biosensing. 5.5 Optical Techniques. 5.6 Advantages and Disadvantages of Nanocrystals in Optical Detection. 5.7 Applications. 5.8 Towards Marketing. 5.9 Conclusions. 6 Quantum Dot-based Nanobiohybrids for Fluorescent Detection of Molecular and Cellular Biological Targets (Zhivko Zhelev, Rumiana Bakalova, Hideki Ohba, and Yoshinobu Baba). 6.1 Introduction. 6.2 Quantum Dots - Basic Principles of Design and Synthesis, Optical Properties, and Advantages over Classical Fluorophores. 6.3 Quantum Dots for Fluorescent Labeling and Imaging. 6.4 Quantum Dots for Immunoblot Analysis with Fluorescent Detection. 6.5 Quantum Dots for FRET Analyses, Time-resolved Fluorimetry, and Development of Optical Recognition-based Biosensors. 6.6 Quantum Dots as New Fluorescent Standards for the Thin Calibration of Fluorescent Instrumentation. 7 Detection of Biological Materials by Gold Nano-biosensor-based Electrochemical Method (Juan Jiang, Manju Basu, Sara Seggerson, Albert Miller, Michael Pugia, and Subhash Basu). 7.1 Introduction. 7.2 Template Synthesis of Gold Nano-wire Arrays for Biosensor Applications. 7.3 Synthesis of a Linker and its Attachment to Gold Posts of GNW followed by Binding to Specific Antibodies. 7.4 Development of Electrochemical Nano-biosensor for Bacteria Detection. 7.5 Conclusions. 8 Dendrimer-based Electrochemical Detection Methods (Hak-Sung Kim and Hyun C. Yoon). 8.1 Overview. 8.2 Introduction. 8.3 Applications for Biosensors. 8.4 Conclusions. 9 Coordinated Biosensors: Integrated Systems for Ultrasensitive Detection of Biomarkers (Joanne I. Yeh). 9.1 Overview. 9.2 Introduction. 9.3 Elements of a Nanobiosensor. 9.4 Coordinated Biosensors. 9.5 Conclusion. 10 Protein-based Biosensors using Nanomaterials (Genxi Li). 10.1 Introduction. 10.2 Metal Nanoparticles. 10.3 Metallic Oxide Nanoparticles. 10.4 Carbon Nanotubes. 10.5 Nanocomposite Materials. 10.6 Nanoparticles with Special Functions. 10.7 Other Nanomaterials. 10.8 Conclusion. 11 Biomimetic Nanosensors (Raz Jelinek and Sofiya Kolusheva). 11.1 Introduction. 11.2 Nanostructures in Biosensor Design. 11.3 Nanosensors for Probing Biological and Cellular Systems. 11.4 Biological Components in Nanosensors. 11.5 Nano-biotechnology and Biomedical Diagnosis. 11.6 Conclusions and Future Directions. 12 Reagentless Biosensors Based on Nanoparticles (David E. Benson). 12.1 Introduction. 12.2 Surface Dielectric Enhancement. 12.3 Catalytic Activation. 12.4 Biomolecule Conformational Modulated Effects. 12.5 Conclusion. 13 Pico/Nanoliter Chamber Array Chips for Single-cell, DNA and Protein Analyses (Shohei Yamamura, Ramachandra Rao Sathuluri, and Eiichi Tamiya). 13.1 Introduction. 13.2 Multiplexed Polymerase Chain Reaction from A Single Copy DNA using Nanoliter-volume Microchamber Array. 13.3 On-chip Cell-free Protein Synthesis using A Picoliter Chamber Array. 13.4 High-throughput Single-cell Analysis System using Pico-liter Microarray. 13.5 Conclusions. Index.