Abstract
Antibiotic resistance in pathogenic bacteria to various types of antibiotics has resulted in the necessity of new effective strategies to get around this problem. In recent investigations, metal or metal oxide nanoparticles specifically silver nanoparticles (AgNPs) have been employed successfully to hinder antibiotic-resistant Gram-negative and Gram-positive bacteria. However, AgNPs at high concentrations have cytotoxicity for eukaryotic cells which, application of other biocompatible materials particularly plant secondary metabolites of curcumin and quercetin to reduce cytotoxicity is a critical affair. These compounds may be used directly or indirectly to produce AgNPs. In this regard, modified NPs by curcumin and quercetin have shown an increased therapeutic effect and biocompatibility and biodegredibility properties. Therefore, here, recent advances and challenges about antibacterial and biocompatibility properties of nanoformulation of AgNPs with curcumin and quercetin are presented.
Highlights
Original paperArticle history: Received: August 20, 2021 Accepted: December 10, 2021 Published: December 15, 2021
Mehran Alavi1*, Nareen Arif Adulrahman2, Azad Abduljabar Haleem3, Ahmed Diyar Hussein AlRâwanduzi4,5, Ameer Khusro6, Mohamed A Abdelgawad7, Mohammed M
Pathogenic bacterial strain with obtaining antibiotic resistance can sidestep the plethora of conventional antibiotics
Summary
Article history: Received: August 20, 2021 Accepted: December 10, 2021 Published: December 15, 2021. AgNPs at high concentrations have cytotoxicity for eukaryotic cells which, application of other biocompatible materials plant secondary metabolites of curcumin and quercetin to reduce cytotoxicity is a critical affair. Nanoparticles metal or metal oxide nanoparticles have a large surface area-to-volume ratio and more reactivity relative to bulk materials appropriate to therapeutic applications such as antibacterial or anticancer agents [11] In this regard, silver (Ag), gold (Au), copper/copper oxide (Cu/CuO), zinc oxide (ZnO2), titanium dioxide (TiO2), and platinum (Pt) are common metallic nanoparticles [12]. AgNPs have shown prominent antibacterial capacity with disadvantages of cytotoxicity in higher doses [13, 14] In this way, conjugation or combination of AgNPs with plant materials curcumin and quercetin has been presented as an effective strategy. This review has discussed this issue in recent years for getting a novel comprehensive scope of future studies
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