Nanocomposites based on halloysite nanotubes and sulphated galactan from red seaweed Gloiopeltis: Properties and delivery capacity of sodium diclofenac

Abstract

We developed novel composite films based on biocompatible components, such as halloysite clay nanotubes and sulphated galactan (Funori) from red seaweed Gloiopeltis. The filling of the nanotubes within the sulphated galactan matrix was carried out by a green protocol (aqueous casting method) assuring that Funori/halloysite nanocomposites can be totally considered as sustainable materials. The amount of halloysite in the composites was systematically changed to explore the effects of the nanofiller concentration on the mesoscopic properties of the films. We observed that the halloysite content significantly affects the initial water contact angle and the light attenuation coefficient of the Funori based films. These results were interpreted according to SEM images, which showed that the surface morphologies of the nanocomposites depend on the halloysite amounts filled within the polymeric matrix. The mechanical characterization of the nanocomposites was conducted by tensile experiments performed using a linear stress ramp. Moreover, tensile tests were conducted in oscillatory regime at variable temperature to investigate the viscoelastic properties of the nanocomposites.Finally, we filled the biopolymeric matrix with halloysite nanotubes containing sodium diclofenac. The drug release kinetics from the nanocomposites at variable halloysite contents were studied to evaluate their suitability as oral dissolving films for pharmaceutical applications.