Abstract
Skin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.
Highlights
Wound healing is an accurate and well-orchestrated process in healthy individuals
Mechanical properties Scaffolds that are intended to be used for wound healing applications should have appropriate mechanical properties that can support cellular activities such as proliferation, migration and angiogenesis, as well as to protect structures found in native skin such as blood vessels, lymphatic systems and nerve bundles [73]
The results showed the potential of the biocompatible angiogenic scaffold for skin tissue engineering applications [159]
Summary
Wound healing is an accurate and well-orchestrated process in healthy individuals. shortcomings in the wound healing lead to more than 38 million patients with chronic wounds worldwide, reaching epidemic proportions, causing a huge economic burden on the healthcare systems [1, 2]. Many strategies to improve skin regeneration are based on stimulating and enhancing angiogenesis In this regard, a promising approach is to use engineered structures, such as scaffolds with or without cells that can mimic the native tissue functionally. Mechanical properties Scaffolds that are intended to be used for wound healing applications should have appropriate mechanical properties that can support cellular activities such as proliferation, migration and angiogenesis, as well as to protect structures found in native skin such as blood vessels, lymphatic systems and nerve bundles [73]. Ion-loaded BGNPs could be incorporated into other polymeric biomaterials to improve their mechanical and biological properties Such nanocomposite scaffolds have shown a good potential for wound healing and skin tissue engineering applications [87, 129].
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