Abstract
AbstractHerein, nano‐hydroxyapatite impregnated chitosan/κ‐carrageenan (nHAp/CHI/κ‐CGN) nanocomposite was prepared through co‐precipitation approach and was compared with nano‐hydroxyapatite/chitosan (nHAp/CHI) nanocomposite for bone regeneration capability. The comparative assessment carried out through Scanning electron microscopy, Fourier transform infra‐red spectroscopy, X‐ray diffraction and mechanical testing revealed rough surface morphology, better interaction between the components, favorable crystallinity, and higher mechanical properties for the nHAp/CHI/κ‐CGN nanocomposite as compared to the bicomponent nanocomposite. Moreover, the in vitro biomineralization study showed increased deposition of apatite layer on nHAp/CHI/κ‐CGN nanocomposite as compared to nHAp/CHI nanocomposite. The cytocompatibility studies carried out using the MG‐63 cell line revealed greater cell viability when cultured in the presence of nHAp/CHI/κ‐CGN nanocomposite as compared to nHAp/CHI. In addition, appropriate swelling ability, enhanced protein adsorption, and favorable degradation rate were also observed for the nHAp/CHI/κ‐CGN nanocomposite. All the results substantiate that nHAp/CHI/κ‐CGN nanocomposite could be a better candidate for bone regeneration.
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