Abstract
Nanochitosan (NC) enriched Poly (ε-caprolactone) (PCL) nanofibrous membranes were fabricated for controlled curcumin delivery and wound dressing. A significant increase in hydrophilicity, PBS sorption, and vapour transmission were observed by incorporation of NC in PCL. Hemolysis assay, blood clot kinetics and platelet adhesion studies on PCL/NC membranes confirmed the hemocompatibility of the scaffold. NC also imparts appropriate antibacterial activity and biocompatibility promising for a wound dressing material. 15% NC (PCL/15NC) loaded membrane exhibits excellent bioavailability and sustained release behaviour of curcumin at different pH of 7.4, 5.8 and 1.2 with pH sensitive nature. Thus, it can be concluded that PCL/15NC nanofibrous membrane is a promising material for wound dressings and transdermal patches with tunable drug releasing properties with pH stimulus.
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