Abstract
Taste is the most crucial organoleptic parameter affecting patient compliance in the case of drugs with poor palatability. Taste masking is a major challenge for the development of orally ingested active pharmaceutical constituents in the pharmaceutical industry. Numerous conventional taste-masking techniques have been extensively studied. In parallel, affecting the drug solubility or release is a major concern of conventional taste-masking techniques. Recently, many nanocarrier systems have been introduced, claiming the advantage of effective taste masking without affecting either the drug solubility or its release. In this review, we will present new techniques for taste masking, including taste-masking techniques utilizing nanocarrier systems such as liposomes, polymeric and solid lipid nanoparticles, polymeric micelles, submicron lipid emulsions, and nanogels. We will chiefly highlight the composition of these systems and their applications in designing oral therapeutic delivery systems successful in masking the taste of bitter molecules.
Highlights
Oral administration, among the multiple routes used to deliver medicines, is the most readily accepted route and used extensively as it offers a lot of advantages such as being easy, self-administrable, and painless which increase patient acceptance and compliance [1].Organoleptic properties are considered crucial criteria for the development of an oral solid dosage form as they could affect consumer liking and compliance [2]
As the majority of the active pharmaceutical ingredients (APIs) show unaccepted palatability or extensive bitterness, taste acceptance is of high concern, especially from the point of formulation development
The mechanism for taste masking of such techniques is based on the physical barrier formed by the nanocarrier systems, which entrap the bitter drug, minimizing or abolishing the contact of the drug with the sensory sites on the tongue
Summary
Among the multiple routes used to deliver medicines, is the most readily accepted route and used extensively as it offers a lot of advantages such as being easy, self-administrable, and painless which increase patient acceptance and compliance [1]. 2022, 90, 20 are surrounded or coated with a continuous film of a polymeric material which could act as a barrier between the drug and the sensory places [11]. Lipoprotein,adsorption system masked the bitter taste of ondansetron HCl, utilizing the excipient, which made of phosphatidic acid and beta-lactoglobulin, selectively suppresses the taste recan delay the reach of the drug to the taste buds [14]. Its taste masking was done by solid dispersion the bitter taste of tablets by a water-insoluble gel formed by sodium alginate and bivalent with mono amino glycyrrhizinate pentahydrate by solvent evaporation method [16].
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