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Abstract
Recent years have witnessed an overwhelming integration of nanomaterials in the fabrication of biosensors. Nanomaterials have been incorporated with the objective to achieve better analytical figures of merit in terms of limit of detection, linear range, assays stability, low production cost, etc. Nanomaterials can act as immobilization support, signal amplifier, mediator and artificial enzyme label in the construction of aptasensors. We aim in this work to review the recent progress in mycotoxin analysis. This review emphasizes on the function of the different nanomaterials in aptasensors architecture. We subsequently relate their features to the analytical performance of the given aptasensor towards mycotoxins monitoring. In the same context, a critically analysis and level of success for each nano-aptasensing design will be discussed. Finally, current challenges in nano-aptasensing design for mycotoxin analysis will be highlighted.
Highlights
The word Mycotoxin is derived from two Greek words “mikes” and “toxin”, meaning “fungi” and “poison”, respectively [1]
Salt induced aggregation of gold NP and disaggregation based on reversible assembly of ssDNA on the surface of particles which promotes the quenching of the dye, is one of the most popular sensing strategies used in fluorescence based aptasensors [96,97,98,99]
Nanomaterials owing to their unique physiochemical characteristics can provide diverse ways to design a variety of aptasensors
Summary
The word Mycotoxin is derived from two Greek words “mikes” and “toxin”, meaning “fungi” and “poison”, respectively [1]. ~ 700) can be produced during harvesting, storage, processing and distribution of crops [2] These mycotoxins contaminate about 25% of world’s food production, based on the report of United Nations of Food and Agriculture Organization. Standardized reference analytical methods for mycotoxins (aflatoxins, ochratoxins, fumonisins, PAT, and DON) detection in food have been made available from different official authorities, such as the European Committee for Standardization (CEN), and international organization for standardization [10,11]. Most of the above-mentioned techniques are very accurate but certain limitations are associated with these techniques such as the high cost, and the need for bulky instruments and skilled persons In this direction, biosensors are very accurate, simple and cost-effective alternatives for a quick on-spot analysis of mycotoxins. The section is focused on the type of nanomaterials that have potential for integration into the fabrication of aptamer assays for mycotoxin analysis
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