Abstract
The trial was aimed at evaluating probable superiority, if any of nano zinc (NZn) over inorganic zinc (Zn) on immunity, serum minerals and T3 , T4 , and IGF-1 hormone profiles in goats. NZn was synthesized by using 0.45M aqueous solution of Zn nitrate and 0.9M aqueous solution of sodium hydroxide (average particle size 74nm). Twenty-four male goats were grouped into four groups as per their body weight and were supplemented with either a basal diet with concentrate and straw at 50:50 ratio (Negative control, NC) alone or supplemented with 50mg/kg Zn (Control) from inorganic Zn source, that is ZnO (IZn-50), 50mg/kg Zn from NZn (NZn-50) or 25mg/kg Zn from NZn (NZn-25). No change was observed in thyroid hormone status on zero and 90th day of experimental feeding, but NZn supplementation improved (p<0.05) IGF-1 level on 90th day serum samples. Zn supplementation improved the humoral immunity in all the groups irrespective of the source. Similarly, cell-mediated immunity (CMI) measured by skinfold thickness after injecting Con-A, was also improved in Zn supplemented groups than control at 6, 12 and 48h of incubation. NZn-50 animals showed highest HI (haemagglutination inhibition) titre as well as skin thickness. The (cluster of differentiation in %) was more (p<0.05) in Zn supplemented groups. NZn-50 showed higher (p<0.05) count than NC and similar (p>0.05) to IZn-50 and NZn-25 groups without affecting (p>0.05) the ratio of , among the treatment groups. Thus, NZn supplementation at 25mg/kg had similar immunity and serum T3 , T4 and IGF-1 profiles compared with IZn at 50mg/kg dose.
Published Version
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