Nano-silver active carbon fiber dressings improving bedsore wound healing in rats

Abstract

Objective To study the effect of nano-silver active carbon fiber dressings on wound healing in bedsore wound animal models.Methods Adult SD rats were used and bedsore wound models were made on their back;the animals were then randomly divided into 5groups(n=10)according to different materials of the wound dressing and treatment.Groups were treated with nano-silver active carbon dressings,nano-silver dressings,active carbon dressings,Vaseline chlorhexidine dressings,or blank control.The wound healing situation,contents of angiogenic factors and inflammatory factors in wound tissues were compared among the 5groups.Results Wound healing time and the healing rates were different among the 5groups,with the healing time of rats in nano-silver active carbon dressing group being significantly shorter than those in the other 4groups(P0.05).On the 3rd,7th,14 th and 21 st days after bedsore wound modeling,the healing rates of nano-silver active carbon dressing group were significantly higher than those of the other 4groups(P0.05).The levels of angiogenesis factors and inflammatory factors were different in wound tissues of five groups,with the contents of VEGFA,VEGFB and VEGFC mRNA in nano-silver active carbon dressing group being significantly higher and the contents of TNF-α,IL-2and IL-8mRNA being significantly lower than those of the other 4groups(P0.05).Conclusion The prepared nano-silver active carbon fiber dressing can help to improve pressure ulcer wound healing,relieve wound inflammation,and promote angiogenesis in the wound;it may serve as an ideal material for treating bedsore wound.