Abstract
Nano interface influences in physiochemical properties of quantum dots (QDs) are the challenging approach to tailor its surface functionalities. In this study, a set of polar and non-polar solvents were selected to analyze the influences in solvent-based dynamic radius and surface potential of QDs. From the nano interface chemistry of polar and non-polar solvents, an appropriate mechanism of precipitation and hydrophobic ligand exchange strategy were elucidated by correlating Henry’s equation. Further, the in vitro cytotoxic potential and antimicrobial activity of QDs were assessed to perform biolabeling. From the observations, an appropriate dosage of QDs was fixed to label the animal ((RAW 264.7 cell lines) and bacterial cells (Escherichia coli) for effective cell attachment. Biolabeling was achieved by tailoring nano interface chemistry of QDs without additional support of biomolecules. Bacterial cell wall-based interaction of QDs was evaluated using SEM and EDAX analysis. Thus, provided clear insights into the nano interface chemistry in the development of highly photostable QDs will be helpful in biomedical applications.
Highlights
Over the past decade, the surface chemistry of nanomaterials has been considered as an active scientific research and a powerful toolkit for materials engineering
Different concentrations of M-CdTe QDs and 10 μL of bacterial suspension were added to a 96-well microtiter plate and total volume was adjusted to 100 μL with LB broth
The optical density was measured at 620 nm under multimode plate reader (Synergy H1, BioTek, USA) and the minimum concentration of M-CdTe QDs with no evident growth was defined as minimum inhibitory concentration (MIC)
Summary
The surface chemistry of nanomaterials has been considered as an active scientific research and a powerful toolkit for materials engineering. Recent reports confirm the zeta potential and electrophoretic mobility mainly depends on the hydrodynamic radius (RH) of the QDs created by solvents (Pyell 2010). Once the precipitation and phase separation of QDs from the organic mixture have been done, the QDs were dispersed in non-polar solvents such as toluene and chloroform to analyze the ligand exchange efficacy of the suitable medium.
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