Abstract
In this work, we report a nano-fluorophore prepared by polymerization-induced self-assembly (PISA) method based on reversible addition-fragmentation chain transfer polymerization. The macromolecular chain transfer agent was polyethylene glycol-based trithiocarbonate, and the monomer was a chalcone derivative terminated with ethylene group. The reaction/assembly was conducted in dioxane, where nanoparticles with extremely uniform size (~200 nm) was formed. The nanoparticles were transferred into aqueous solution, and shrank to ~100 nm with excellent dispersion. The nanoparticles showed fluorescence emission at around 570 nm, and after being transferred to aqueous solution, the emission intensity was significantly enhanced. Being covered with hydrophilic polyethylene glycol, the nano-fluorophores possess excellent biocompatibility, and was successfully applied to label HeLa cells for fluorescent imaging. This study presents a novel avenue for including fluorescent dyes into polymeric nanoparticles with narrow size-distribution, tailorable solubility and biocompatibility.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
