Abstract
AIM: To investigate the therapeutic effect of acupuncture at He-Sea point and Front-Mu point of the stomach meridian on gastric stress ulcer (SU) in rats and to explore potential mechanisms involved. METHODS: Thirty-five Wistar rats were randomly divided into five groups: blank control group, model group, He-Sea point (Zusanli) group, Front-Mu point (Zhongwan) group, and He-Sea and Front-Mu point (He-Mu) group. Gastric SU was induced in rats by water immersion and restraint. Proteomic alterations in the stomach of rats were analyzed by nano-twodimensional liquid chromatography (nano-2DLC). RESULTS: Five chromatographic peaks at a retention time between 27 and 32 min were noted on the chromatograms in the model group and acupuncture treatment groups. The retention time of these five peaks was basically identical. The peak area was largest in the model group, followed by the Front-Mu point group, He-Sea point group and He-Mu group. CONCLUSION: Acupuncture at He-Sea point and Front-Mu point exerts a therapeutic effect on SU possibly by altering the expression of some proteins.
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