Abstract
Three new structurally unique bromopyrrole alkaloids, nagelamides U–W (1–3), were isolated from a marine sponge Agelas sp. Nagelamides U (1) and V (2) possess a γ-lactam ring with an N-ethanesulfonic acid and guanidino moieties, while nagelamide W (3) has two aminoimidazole moieties in the molecule. The structures of 1–3 were elucidated on the basis of spectroscopic data. Nagelamides U (1) and W (3) exhibited antimicrobial activity against Candida albicans.
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