NADC30-Like Porcine Reproductive and Respiratory Syndrome in China.

Kegong Tian

doi:10.2174/1874357901711010059

Abstract

NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) has widely spread in China and become locally dominant virus strain in some provinces. Although they are not pathogenic as highly pathogenic PRRSV (HP-RRRSV) that outbreaks since 2006, NADC30-like PRRSVs distinguished themselves by high incidence of recombination with other virus strains which lead to change of virulence. The outbreaks of NADC30-like PRRSV in the vaccinated pig herds suggested that current commercial PRRSV vaccines cannot provide complete protection to the infection. In this review, we have described in detail the current situation of NADC30 PRRSV including epidemiology, genomic characterization, pathogenicity, and efficacy of current commercial vaccines in China.

Highlights

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases of pigs worldwide [1]
We have described the genomic characteristics and pathogenicity of NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) as well as the efficacy of current commercial vaccines to NADC30-like PRRSV
Even though the parental NADC30 has limited pathogenicity to pigs, the risks of its recombination with other virus strains which lead to the emergence of highly pathogenic PRRSV such as JL150 will severely endanger local pig industry

Summary

Introduction

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases of pigs worldwide [1]. Compared to the highly pathogenic PRRSV (HP-PRRSV) which has emerged and become the dominant circulating strain in China since 2006, the virulence of NADC30-like PRRSV is relative milder which has led to clinical respiratory symptoms with 30-50% fatality rate on pigs [12, 14, 15]. The outbreak of NADC30-like PRRSV in vaccinated pig herds indicated the inefficacy of current commercial vaccines [12].

Results

Conclusion