N-Substituted hydroxylamines as synthetically versatile amino sources in the iridium-catalyzed mild C-H amidation reaction.

Abstract

N-Substituted hydroxylamines such as aroyloxy- or acyloxycarbamates were successfully employed as synthetically versatile amino precursors in the iridium-catalyzed direct C-H amidation of arenes. The reaction proceeds smoothly at room temperature over a broad range of substrates with high functional group tolerance to afford N-substituted arylamine products.