Abstract
N-(2-Nitrophenylsulfonyl)- (o-NBS-AA-OMe, 4) and N-(4-Nitrophenylsulfonyl)-α-amino acid methyl esters (p-NBS-AA-OMe, 5) were N-alkylated with a variety of alkyl halides 6 under solid-liquid phase-transfer catalysis (SL-PTC) conditions, affording the alkylated products o-NBS-N-R2-AA-OMe 7 and p-NBS-N-R2-AA-OMe 8 in excellent yields without any detectable racemization.
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