S,S-Dimethyl Dithiocarbonate as a Valuable Starting Material for the Synthesis of 5-Substituted Oxazolidinones Under Solid-Liquid Phase Transfer Catalysis (SL-PTC) Conditions

Abstract

N-Alkyl and N-aryl 5-substituted oxazolidinones 12-19 were prepared in good to excellent yields by reaction of N-alkyl and N-aryl 1,2-amino alcohols 3-10 with S,S-dimethyldithiocarbonate (11) in the presence of solid NaOH under SL-PTC conditions. The procedure is particularly suitable for scale-up the process involving the use of cheap and ecosafe reagents under mild reaction conditions. Keywords: S,S-dimethyldithiocarbonate, 1,2-amino alcohols, 5-substituted oxazolidinones, phase-transfer catalysis, carbonylation reaction