Year-end Sale % OFF 
Abstract
N‐Methyl‐C‐(trichlorotitanio)formimidoyl Chloride, a Highly Efficient Reagent for Homologations of Aldehydes and Ketones to α‐HydroxycarboxamidesThe known title compound 6 formed by addition of titanium tetrachloride to methyl isocyanide in methylene chloride adds to the carbonyl group of aldehydes and ketones. The adducts 7 are hydrolized to N‐methyl‐α‐hydroxycarboxamides 8 which are (from ketones) or are not branched (from aldehydes) in the α‐position. The yields in this new modification of the Passerini reaction are near 90%, also with readily enolized ketones such as acetone and acetophenone. In contrast to the previously used organotitanium reagents of the type RTiX3, the preparation of the reagent 6 does not require any Li‐, Mg‐ or Zn‐derivative as a precusor.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
