Abstract
The qualities of 2 suppositories (A and B) containing 75mg of Ketoprofen on the market were evaluated in the points of weight variation, content uniformity, and release from suppository bases. Release tests were made by the modified method of the rotating basket and the paddle method of J. P. X. In the paddle method, the suppository was put in the cellulose tube (the cellulose tube method) or in the net (the net method). The release fluid was phosphate buffer solution at pH 7.2.Following results were obtained: 1) The weight variations of both preparations were very small. 2) The content uniformities of both preparations were sufficient. 3) In the rotating basket method, the release of preparation A at 8 hours was about 50%, but that of B was about 20%. 4) In the cellulose tube method, the releases of both preparations at 8 hours were about 40%. 5) In the net method, the release of preparation A at 2 hours was about 100%, that of B at 4 hours was about 75%.
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