Abstract
The rates of oxygen consumption of the various tissues of the male albino rats were measured by Warburg manometric method under the hypoxic conditions.Oxygen consumption rates of various tissues (muscle, liver, kidney, brain, testicle, adrenal and thyroid) of the rats which were killed by ether anesthesia were significantly elevated, whereas the rats which were decapitated after a series of repeated ether anesthesia for 10 days were decreased, comparing with those of rats which were decapitated simply.Brain tissue was most sensitively reacted to the variation of partial pressure of oxygen, but brain tissue also showed some adaptability to chronic histotoxic stress such as ether anesthesia.From analyses of the experimental data, the following conclutions might be said:(1) Brain tissue was most sensitive to hypoxia.(3) Not only the intact organism, but also every kinds of tissue slice showed so-called stress reaction-like responses.(3) Among others, testicular tissue showed the most marked adaptability to hypoxic conditions such as simple hypoxia or histotoxic hypoxia like chronic ether anesthesia.(4) Adrenal tissue showed most remarkable resistance to chronic stress such as histotoxic hypoxia. This fact might have certain relation with the role of adrenal gland in general stress reactions.(5) Acute ether intoxication induces acute asphyxia rather than histoxic hypoxia, and acts as acute stressor to the organism. However chronic ether anesthesia induces obviously histotoxic hypoxia.(6) Decrease of the oxygen consumption rates of various tissue in low temperatures is purely due to the depression of the intracellular enzymatic reaction velocity.
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