Abstract
Administration of porcine pancreatic elastase (Ela.) is reported to have anti-atherosclerotic effect. To clarify the precise mechanism, effects of Ela. on lipid metabolism in rabbit arterial wall were studied. Three groups of rabbits were kept for 4 months as follows; Ist group was fed normal diets, IInd group was fed 1% cholesterol diet and IIIrd group was fed 1% cholesterol diet and was injected with Ela. 5mg/kg/day intraperitoneally.Total cholesterol content in the arterial wall was lower in group III than in group II. Serum cholesterol and triglyceride level were lower in group III than in group II, and those contents in VLDL and LDL fraction were decreased in group III comparing with group II. Acid cholesterol esterase, neutral cholesterol esterase and acyl CoA cholesterol acyl transferase activity in the arterial wall in group III were not significantly different from those in group II. The binding of cholesterol (1-14C) oleate labelled LDL to 800×g pellet fraction of arterial wall homogenate in group II was increased comparing with that in group I. When cholesterolloaded aorta was treated with Ela., the binding of LDL to the 800×g pellet fraction was decreased. These results may suggest that Ela, had antiatherosclerotic effect by reducing serum VLDL and LDL levels and decreasing the binding of LDL to the arterial wall.
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