Abstract
Recent advances in the field of organocatalytic asymmetric synthesis have provided several new methods for preparing chiral compounds in an environment-friendly manner. Among them, proline-catalyzed asymmetric aldol reactions gather a considerable attention from synthetic chemists. In our recent work on the synthesis of (5R,6S)-(−)-6-acetoxy-5-hexadecanolide, we found that aldehydes bearing a 1,3-dithiane moiety at the β-position could serve as a useful synthon of straight-chain aliphatic aldehydes. This method has been successfully applied to the enantioselective synthesis of biologically interesting natural products such as (+)-boronolide, D-ribo-C18-phytosphingosine, pachastrissamine, and (+)-prosophylline.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
