Recent Advances in Asymmetric Reactions Catalyzed by Proline and Its Derivatives

Abstract

Asymmetric reactions are carried out by organocatalysis in many ways, making them very competitive and practical. One remarkable molecule, the amino acid proline, has become a crucial component in organocatalysis because of its ability to promote chemical transformations with high enantioselectivity. The following review discusses the contributions and recent advances in the field of asymmetric reactions catalyzed by l -proline and its derivatives. 1 Introduction 2 Asymmetric Aldol Reactions Catalyzed by Proline and Its Derivatives 2.1 Reactions of Ketones as Aldol Donors with Aldehydes as Aldol Acceptors 2.2 Reactions of Aldehydes as Aldol Donors with Aldehydes as Aldol Acceptors 2.3 Reactions of Aldehydes as Aldol Donors with Active Ketones as Aldol Acceptors 2.4 Reactions of Ketones as Aldol Donors with Active Ketones as Aldol Acceptors 3 Asymmetric Mannich Reactions Catalyzed by Proline and Its Derivatives 4 Asymmetric Michael Reactions Catalyzed by Proline and Its Derivatives 5 Asymmetric α-Amination Reactions Catalyzed by Proline and Its Derivatives 6 Conclusion