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Abstract

Background and Aim: Angiotensin-converting enzyme 2 receptor (ACE2), together with Transmembrane protease serine 2 (TMPRSS2), is a protein receptor for SARS-CoV-2 virus in the host subject; expression of ACE2 and TMPRSS2 reveals the multidimensional character of COVID-19 infection. SARS-CoV-2 prominently induces pulmonary and systemic injury with other synergistic mechanisms. Preexisting chronic inflammatory conditions markedly sustain and aggravate the severity and cytokine storm. Inflammatory responses are closely linked with COVID-19 severity and complications. Role of Reactive oxygen species (ROS) is crucial and owing the demand of polyherbal combinations with antioxidant potential for their preventive and therapeutic aspects. Ayurveda intended to develop potential immune mechanism in the host while dealing with infectious diseases. ‘Kamsaharitaki’ a polyherbal formulation predominantly indicated in inflammatory conditions targeting multiple systems is found to be most appropriate to restrain Multisystem inflammatory syndrome (MIS) associated with COVID 19. To support and establish this; phytopharmacological exploration is decisive. Methodology: A keen exploration of in vitro, in vivo studies with electronically published data limited to Pubmed search engine interrelated to phytochemicals and pharmacological properties of each solitary herb along with predefined groups of herbs constituting this formulation is carried out. Results and Conclusion: This revealed presence of numerous phytochemicals with comparable pharmacological properties. Dashmula (group of 10 herbs of this formulation) illustrated statistically significant anti-inflammatory, antioxidant and anti-platelet (P<0.05) potentials. Terminalia chebula, a chief constituent, exhibited 3CLpro inhibitory potential and other ingredients possess supportive properties. This will provide a potential evidences for further research.