Abstract
Eugenol is a main ingredient of clove oil, and either eugenol or clove oil is important constituent in various dental preparations. Rather strong allergenicity of eugenol was confirmed in examination with two methods of modified guinea pig maximization test, which is called adjuvant and patch test, and ear swelling test in mice. Possibility that delayed contact hypersensitivity is induced by use of an eugenol preparation must be admitted. It is found that eugenol in various dental preparations is applied to contact with gingiva or teeth in an enough concentration to cause hypersensitivity especially in the case of some zinc oxide-eugenol preparations such as periodontal dressings and root canal cements. On the other hand clove oil and eugenol are more widely and frequently used for cosmetic and food processing than for dental treatment, and there would be many opportunities in man to get hypersensitivity to eugenol. Even in the case of a new patient the correlation between the allergic symptoms and dental treatment will give rise to the supposition that an eugenol preparation is causing the trouble.
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