Abstract
Immunohistochemical localization of SCC antigen was investigated to evaluate its usefulness as a tumor marker in salivary gland disease. SCC antigen levels were measured in both sera and tissues from 14 salivary disease patients. SCC antigen was confirmed to be localized in cancer cells of mucoepidermoid tumors and adenoid carcinomas, but was not present in adenoid cystic carcinomas. In pleomorphic adenoma, SCC antigen displayed interesting localization patterns; the antigen localized in the ducts, squamous epithelium and keratin formations. However, it was absent in the myxomatous area and myoepithelium cells. Therefore, SCC antigen was found to be impractical as a tumor marker in salivary gland tumors for two reasons;(a) There was no localization in adenoid cystic carcinoma, and (b) Serum SCC antigen levels were low in salivary malignant disease patients. On the other hand, this study suggests that the investigation of tissue SCC antigen can be useful for differential diagnoses of salivary gland diseases and also in the application of the study of their origin and differentiation.
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