Abstract
The susceptibilities of various antiseptics toStaphylcoccus aureuscarrying antiseptic-resistance genes, qacA, smr and/or mutatednorA, were evaluated by a method to determine the minimum bactericidal concentration (MBC) and the minimum inhibitory concentration (MIC). In benzalkonium chloride, benzethonium chloride and alkydiaminoethylglycine hydrochloride, which are used for the washing of hands, skin-surfaces and wounds, we observed, in terms of MIC, no clear difference between the strains with and without antiseptic-resistance gene (s). However, we found that, in the modified method of MBC using a neutralizer, antiseptic-resistant strains survived after exposure to those antiseptics for 5 min at the minimum standard concentration (100μg/mL). The results showed that S.aureusstrains carrying antiseptic-resistance gene (s) exhibited resistance to various antiseptics. Therefore, the modified determination of MBC was thus found to be useful for evaluating the susceptibility of antiseptics to antiseptic-resistant S.aureus.
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