Abstract
200mg of valproic acid (VPA) was orally administered to 7 healthy adults at 9 a.m. and 9 p.m. for 5 days. On the 6th day, blood samples were collected at 0, 10, 20, 30, 45, 60, 90, 180 and 360 min and the obtained 63 sera were prepared for analysis. There was a significant relationship between VPA dose and total VPA concentration in the serum, the regression curve was y=0.330x2+22.051 (r=0.469, p<0.001). After the last dose, maximum change of total VPA concentration reached at 60 min and the value was 84.0±29.9%(mean±S.D. n=7). Maximum change of unbound VPA fraction reached at 90 min and the value was 26.6±33.2%(mean±S.D. n=7).At 360 min, the coefficient of variation of total VPA concentration change was 30.7% and that of unbound VPA fraction change was 191.5%. Protein binding of VPA showed a tendency to depend on its total concentration in the serum.
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