薬物の中枢興奮作用とアミンオキシダーゼ活性及び脳組織呼吸に及ぼす影響について

Abstract

Relationship between awakening effect and inhibitory action of amine-oxidase activity of a drug, discovered by Mann, Quastel, and Ohta, was examined systematically by the use of analeptics, such as methylpropamin, dimethylpropamin, and 2-(3, 4-methylene-dioxyphenyl) isopropylamine, and a series of other pharmaceuticals. Further examinations were made on the possibility of the use of this point as a supplementary means in the judgement of potency of awakening effect, which is difficult to be obtained from animal tests. At the same time, effect of these pharmaceutics on brain tissue respiration was tested with a rabbit. Majority of these pharmaceutics indicated inhibitory action on amine-oxidase activity in greater or lesser degree and the levorotatory compound of analeptics, which does not indicate awakening effect in human body, inhibited amine-oxidase activity, same as dextrorotatory compound. It was found that the correlationship between awakening effect and inhibition of amine-oxidase activity was exceptionally weak. At the same time, these pharmaceutics indicated weak inhibitory action on tissue respiration but there seemed to be no correlation between that and awakening effect.