Abstract
Bone marrow transplantation (BMT) is now a promising therapy for a variety of hematopoietic and immunodeficiency diseases that are otherwise impossible to treat effectively. Graft versus host reaction (GVHR) following BMT has been one of the major problems for immunologically incompetent recipients. However, GVHR has two different features. Minor GVHR prompts full replacement of recipient lymphoid tissues by donor cells which may lead to eradication of malignant cells in leukemia patients. On the other hand, GVHR results in immunological suppression and modification of T cell repertoire among donor derived lymphocyte population. The latter influence is mainly attributed to the agressive response of donor mature T cells against thymic stromal components that are involved in positive or negative selection of thymocytes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
