Abstract
Serial serum samples from 16 patients who received blood transfusions and underwent operations in the Department of Surgery, National Medical Center Hospital, were examined for circulating immune complexes (IC) by Clq solid phase radioimmunoassay.Eight of the 10 patients who were considered to suffer from transfusion-associated non-A, non-B (NANB) hepatitis had increased IC levels, while only one of the 6 patients with normal serum glutamic pyruvic transaminase (SGPT) had increased IC levels. The difference was significant by X2 test. There were three types in respect of the time of elevated IC levels; i. e., immediately before, coincident with, or during the return to normal of raised SGPT.In five of the 8 patients, the molecular size of IC was analysed by gel filtration on Sepharose 6B. Only 2 of the 5 patients with high IC levels showes increased Clq binding activity in fractions of intermediate size.It was suggested that analysis of the molecular size of IC is important for trying to detect virus-associated antigens in IC in NANB hepatitis.
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