Abstract

目的:本项研究主要是以吉林省北缬草为研究对象,收集北缬草样品,对其进行文献查考、生药学鉴定、化学成分含量测定与分析方面的研究。方法:采用2015版《中国药典》规定的方法进行浸出物测定和挥发油测定,采用薄层色谱法鉴别缬草中的橙皮苷及绿原酸成分。采用高效液相色谱法进行缬草中缬草素的含量测定。结果:描述了北缬草根及根茎的性状特征。水溶性浸出物含量为9.23%,醇溶性浸出物的含量为3.48%,挥发性醚浸出物含量为1.28%。通过薄层鉴别确定成分中含有橙皮苷和绿原酸。高效液相色谱法测得缬草素的含量为5.29 mg/g。结论:本实验进行的生药学鉴定,化学成分含量测定与分析方面的研究,可以为吉林省北缬草的药用价值利用提供理论指导,为深入研究开发该中药提供参考。 Objective: This study mainly regards north of valerian in Jilin province as the research object, collecting samples of the north valerian and researching by literature review, pharmacognosy, chemical composition analysis and determination. Methods: The determination of extractives and volatile oil refers to the method provided in Chinese Pharmacopoeia 2015, identifying the hesperidin and chlorogenic acid composition of valerian by TLC to determine the content of valerian pigment by HPLC. Results: It describes the characteristics of roots and rhizomes of north of valeriana. The content of water soluble extract was 9.23%, the content of alcohol soluble extract was 3.48%, the content of volatile ether extract was 1.28%. In this study, the determination of hesperidin and chlorogenic acid was through TLC. Valerian pigment measured by HPLC was 5.29 mg/g. Conclusion: The experiment of Pharmacognosy identification, research and analysis of the determination of chemical compositions, can be used to provide theoretical guidance for the medicinal value of north of valerian in Jilin province, to provide reference for further research and development of the Chinese traditional medicine.

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