Abstract
In 40 patients diagnosed as having head and neck region malignant tumors, we studied the changes of peripheral blood lymphocyte and its subpopulation using OK and T series monoclonal antibody.We divided the patients into three classes: good prognostic cases (13 cases), cancerous cases (16 cases) and death cases (11 cases).Peripheral blood lymphocyte showed tendencies of decreases in the following order: good prognostic cases, cancerous cases and death cases (p<0.01).In death cases, 8 cases (73%). showed that the number of peripheral blood lymphocyte was under 1, 000/mm3.We found no significant correlation in both the percentage and the number of OKT-1+ & NKH-1+.The percentages of OKT-3+ & OKT-8+ showed tendencies of increases in the following order: good prognostic cases, cancerous cases and death cases.But, the number of OKT-3+, decreased in the following order: good prognostic cases, cancerous cases and death cases (p<0.05). The number of OKT-8+, showed the same order of decreases as above.The percent and the number of OKT-4+, decreased in the following: good prognostic cases, cancerous cases and death cases (p<0.05, p<0.01).The “T helper/T suppressor” ratio (OKT-4+/OKT-8+) showed significant increases in the following order: death cases, cancerous cases and good prognostic cases (p<0.01).We considered most probable that the decline of the immunological capacity in head and neck region malignant tumor patients were caused by the decreases in the number of OKT-4+.
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