めまい症例に対するＡＴＰの臨床治験

Abstract

It is generally accepted that ATP markedly improves cerebral blood flow and inner ear metabolism, and depresses vestibular responses. The antivertiginous effects of ATP were evaluated in a single controlled study in 82 patients with vertigo and/or dizziness.The clinical subjective signs and symptoms in these cases were evaluated every two weeks both by the doctors and the patients themselves. The objective symptoms in the equilibrium and auditory examinations were also evaluated at the first examination before prescribing treatment, the second after two weeks, and the last after four weeks, by the same doctors. Dosage was 300mg of ATP daily for four weeks.The global comparative judgement of the subjective and objective clinical findings showed antivertiginous drug effects in 46 out of 81 patients (56.8%) after four weeks ingestion. When the effects of ATP after two weeks ingestion were compared with those after four weeks, there was a significant improvement in the latter.Side-effects were minimal, and only three patients reported occipital headache, thirst and fatigue.