Abstract
Liposome-entrapped adriamycin (ADM-Lip) as hospital pharmacy product for injection was investigated for improving therapeutic effects of adriamycin. ADM-Lip was prepared from egg phosphatidylcholine, cholesterol and stearylamine (molar ratio, 3: 3: 1), and separated from free adriamycin by dialysis. It was stable in dialysate of 0.01 M phosphate buffer with 0.85% NaCl (pH 7.4) at 37°. ADM-Lip increased the octanol-water partition coefficients to about 30 times as compared with those of the free form. Size of most ADM-Lip particles was less than 0.4μm and, therefore, ADM-Lip could be prepared as sterile injection by filtration through 0.45μm membrane filter.
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