Abstract
Since the discovery of industrial bladder cancer by Rehn in 1895, many incidences of the occupational bladder cancer have been reported with the progress of dyestuff industry. On the other hand, various industrial bladder carcinogens have been found in aromatic amines of dyestuff intermediates experimentally and epidemiologically. The biochemical mechanisms that the metabolites of the parent aromatic amines have more potent carcinogenic action than the parent chemicals have been found. From these findings, some chemicals being slightly changed in their chemical structure were produced and it was found that these chemicals were usefull for dyestuff intermediates as well as quite safe for cancer induction. It is very necessary for the prevention that new aromatic amines should be checked in order to know whether they are carcinogenic or not. From this point of view, 5-aminoacenaphtene and 5-nitroacenaphthene, the intermediates of fluorescent whitening agents, were examined by the author, and it was proved experimentally that these new aromaiic amines have carcinogenic action to mice.
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