ストレス負荷による代謝変化の動脈硬化に及ぼす影響について

Abstract

According to many previous papers, various stress stimuli are said to be closely linked to cardiovascular disorders. And hyperlipidemia is one of several factors to which the onset and progress of atherosclerosis can be attributed. In this paper, we studied the effect of stress load on the progress of atherosclerosis in connection with the changes in the catecholamines, PGI2, and TXA2 in plasma using rabbits on a high-cholesterol diet.Fat deposition in the aorta was well defined in rabbits treated with a high-cholesterol diet and stress compared to that of the rabbits reared on high-cholesterol diet without stress. For 5 months the rabbits were subjected daily to sonic stress and twice a week to water immersion stress.The increase in catecholamine in plasma after acute stress of water immersion was nearly the same in two groups of rabbits which were reared on a normal and high cholesterol group, whereas the increase in plasma TXA2/6 keto PGF1α ratio in Ch (+) St (+) group was significantly higher than that in the Ch (-) St (+) group.These observations indicate that the effect of stress loading is amplified under high-cholesterol conditions and that the imbalance of the TXA2/PGI2 ratio is an important factor in the progress of fat deposition.